Neuroprotection, cognition, brain function, inflammation, heart health*

Looking to keep a sharp mind and protect you neuro-biology? Lion’s mane might have benefits of interest to you! 

Lion’s mane is often called the “smart mushroom” as studies suggest that active components in lion’s mane have neuroprotective properties that help your neurons/brain cells repair and grow. Which by many is experienced by improved cognitive function.

Some studies even argue that the lion’s mane can promote neurite - which is the process of a neuron (brain cell)  growing into new connections. This process can be important in preventing or even reversing the neuro-degenerative damage happening from illnesses such as Alzheimer's, Multiple Sclerosis or Dementia.

Lion’s mane and microdosing

Many people choose to combine their microdosing with lion’s mane, as it is reported to have a synergistic effect between the neuroplastic stimulation from psilocybin, and the promotion of neural growth from lion’s mane. This combination of lion’s mane, psilocybin - and niacin (a B3 vitamin) is also referred to as the Stamets Stack, named after Paul Stamets, the famous mycologist, who advocate for this combination. ( the*dose lion’s mane product contains niacin, thus making it the perfect product for people who want to work with the Stamets Stack.)

Research also suggests that lion’s mane might help wounds heal faster, reduce inflammation and improve the health of our heart.

Science & Research

Here's a look at some key study findings:

• Abdulla, M. A., Fard, A. A., Sabaratnam, V., Wong, K. H., Kuppusamy, U. R., Abdullah, N., & Ismail, S. (2011). Potential activity of aqueous extract of culinary-medicinal lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats [Abstract]. International Journal of Medicinal Mushrooms, 13(1), 33–39
  https://www.ncbi.nlm.nih.gov/pubmed/22135902
  
  
• Abdullah, N., Ismail, S. M., Aminudin, N., Shuib, A. S., & Lau, B. F. (2012). Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. Evidence-Based Complementary and Alternative Medicine, 2012
  https://www.hindawi.com/journals/ecam/2012/464238/
  
  
• Brandalise, F., Cesaroni, V., Gregori, A., Repetti, M., Romano, C., Orrù, G., ... Rossi, P. (2017, January 1). Dietary supplementation of Hericium erinaceus increases mossy fiber-CA3 hippocampal neurotransmission and recognition memory in wild-type mice. Evidence-Based Complementary and Alternative Medicine, 2017
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237458/
  
  
• Chiu, C.-H., Chyau, C.-C., Chen, C.-C., Lee, L.-Y., Chen, W.-P., Liu, J.-L., ... Mong, M.-C. (2018, February). Erinacine A-enriched Hericium erinaceus mycelium produces antidepressant-like effects through modulating BDNF/PI3K/Akt/GSK-3β signaling in mice. International Journal of Molecular Sciences, 19(2), 341
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855563/
  
  
• Choi, W.-S., Kim, Y.-S., Park, B.-S., Kim, J.-E., & Lee, S.-E. (2013, June 30). Hypolipidaemic effect of Hericium erinaceum grown in Artemisia capillaris on obese rats. Mycobiology, 41(2), 94–99
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714447/
  
  
• Diling, C., Chaoqun, Z., Jian, Y., Jian, L., Jiyan, S., Yizhen, X., & Guoxiao, L. (2017, June 12). Immunomodulatory activities of a fungal protein extracted from Hericium erinaceus through regulating the gut microbiota. Frontiers in Immunology, 8, 666
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492111/
  
  
• Kim, S. P., Kang, M. Y., Choi, Y. H., Kim, J. H., Nam, S. H., & Friedman, M. (2011, June 8). Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells [Abstract]. Food & Function, 2(6), 348–356
  https://www.ncbi.nlm.nih.gov/pubmed/21779573
  
  
• Lakshmanan, H., Raman, J., David, P., Wong, K. H., Naidu, M., & Sabaratnam, V. (2016, December 24). Haematological, biochemical and histopathological aspects of Hericium erinaceus ingestion in a rodent model: A sub-chronic toxicological assessment [Abstract]. Journal of Ethnopharmacology, 194, 1051–1059
  https://www.ncbi.nlm.nih.gov/pubmed/27816657
  
  
• Li, G., Yu, K., Li, F., Xu, K., Li, J., He, S., ... Tan, G. (2014, April 28). Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers [Abstract]. Journal of Ethnopharmacology, 153(2), 521–530
  https://www.ncbi.nlm.nih.gov/pubmed/24631140
  
  
• Liang. B., Guo, Z., Xie, F., & Zhai, A. (2013, October 3). Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complementary and Alternative Medicine, 2013(13), 253
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852124/#__ffn_sectitle
  
  
• Liu, J. H., Li, L., Shang, X. D., Zhang, J. L., & Tan, Q. (2016, May 13). Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus [Abstract]. Journal of Ethnopharmacology, 183, 54–58
  https://www.ncbi.nlm.nih.gov/pubmed/26364939
  
  
• Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009, March). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double‐blind placebo‐controlled clinical trial [Abstract]. Phytotherapy Research, 23(3), 367–372
  https://www.ncbi.nlm.nih.gov/pubmed/18844328
  
  
• Nagano, M., Shimizu, K., Kondo, R., Hayashi, C., Sato, D., Kitagawa, K., & Ohnuki, K. (2010, August). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomedical Research, 31(4), 231–237
  https://www.jstage.jst.go.jp/article/biomedres/31/4/31_4_231/_pdf/-char/en
  
  
• Samberkar, S., Gandhi, S., Naidu, M., Wong, K. H., Raman, J., & Sabaratnam, V. (2015). Lion's mane, Hericium erinaceus and tiger milk, Lignosus rhinocerotis (higher basidiomycetes) medicinal mushrooms stimulate neurite outgrowth in dissociated cells of brain, spinal cord, and retina: An in vitro study [Abstract]. International Journal of Medicinal Mushrooms, 17(11), 1047–1054
  https://www.ncbi.nlm.nih.gov/pubmed/26853959
  
  
• Sheng, X., Yan, J., Meng, Y., Kang, Y., Han, Z., Tai, G., ... Cheng, H. (2017, March 22). Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology [Abstract]. Food & Function, 8(3), 1020–1027
  https://www.ncbi.nlm.nih.gov/pubmed/28266682
  
  
• Wang, M., Konishi, T., Gao, Y., Xu, D., & Gao, Q. (2015). Anti-gastric ulcer activity of polysaccharide fraction isolated from mycelium culture of lion's mane medicinal mushroom, Hericium erinaceus (higher basidiomycetes) [Abstract]. International Journal of Medicinal Mushrooms, 17(11), 1055–1060
  https://www.ncbi.nlm.nih.gov/pubmed/26853960
  
  
• Wong, K.-H., Naidu, M., David, P., Abdulla, M. A., Abdullah, N., Kuppusamy, U. R., & Sabaratnam, V. (2011, August 11). Peripheral nerve regeneration following crush injury to rat peroneal nerve by aqueous extract of medicinal mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evidence-Based Complementary and Alternative Medicine, 2011
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176599/
  
  
• Yao, W., Zhang, J. C., Dong, C., Zhuang, C., Hirota, S., Inanaga, K., & Hashimoto, K. (2015, September). Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration [Abstract]. Pharmacology, Biochemistry, and Behavior, 136, 7–12
  https://www.ncbi.nlm.nih.gov/pubmed/26150007
  
  
• Yi, Z., Shao-long, Y., Ai-hong, W., Zhi-chun, S., Ya-fen, Z., Ye-ting, X., & Yu-ling, H. (2015, April 16). Protective effect of ethanol extracts of Hericium erinaceus on alloxan-induced diabetic neuropathic pain in rats. Evidence-based Complementary and Alternative Medicine, 2015
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415746/
  
  
• Zhang, J., An, S., Hu, W., Teng, M., Wang, X., Qu, Y., ... Wang, D. (2016, November 1). The neuroprotective properties of Hericium erinaceus in glutamate-damaged differentiated PC12 cells and an Alzheimer's disease mouse model. International Journal of Molecular Sciences, 17(11), 1810
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133811/

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